Posts Tagged: "organ transplant"

Paul Terasaki Revolutions Organ Donor-Recipient Matching With the Terasaki Tray

This July 8th marks the 32nd anniversary of the issue of a seminal patent in the field of organ donation and it protected a technology which became crucial for testing organ tissues to determine potential matches between organ donors and recipients. The lead inventor listed on this patent is Paul Terasaki, a 2018 inductee into the National Inventors Hall of Fame. Once again, we return to our Evolution of Technology series to take a look at the history of organ transplants, the technology that has been developed to improve the success of those transplants and where Terasaki’s innovation fits into that story.

Federal Circuit Affirms District Court Judgment on All Grounds in LifeNet Health v. LifeCell

Lifenet’s patent is for plasticized soft tissue grafts used for transplantation in humans. The specification discloses that plasticizers can be removed before implantation, although they need not be, as claim 1 discloses three options for the implanting technician, one option being direct implantation without removing plasticizers. LifeCell’s accused grafts are preserved in a solution prior to implantation, and it is undisputed that significant amounts of plasticizers are removed during this soaking process. During claim construction, the parties disputed the meaning of the term “non-removal.” The district court concluded that construction of this term was unnecessary because it was easily understood by a person of ordinary skill in the art to have its plain meaning.

University research leads to breakthroughs in 3D printed organs

In the middle of February, the scientific journal Nature Biotechnology published a paper from a team of researchers at Wake Forest University which reported a breakthrough in creating transplantable human organs with the use of an integrated tissue-organ printer. The Wake Forest breakthrough provides 3D printed tissues with a biodegradable material to serve as a temporary framework for cells as they take hold in a host body; the tissue material also enables oxygen and nutrients to flow into the printed organ more easily. Still, issues in tissue complexity for certain organs remain, although we are closer than ever to the world’s first 3D printed liver thanks in part to work performed by engineers at the University of California, San Diego.