Posts Tagged: "Alzheimer’s Disease"

Assessing How Much an Alzheimer’s Drug is Worth

On June 7, 2021, the U.S. Food and Drug Administration (FDA) gave the green light to Aducanumab, a drug developed by Biogen to treat early stage Alzheimer’s, despite the controversies surrounding its efficacy. Biogen stock price increased 38.3% on the day, adding $16.5 billion to the company’s market value. The news rippled across the pharmaceutical industry and lifted stock prices of most Alzheimer’s drug developers. As an example, Eli Lilly stock price jumped 10.2% on June 7, or a hike of $18.6 billion in market cap, because the company also has a similar drug candidate. Subsequently, as the controversies over the Aducanumab approval deepened, Biogen had lost $7 billion in market value by September 9. With all of these multi-billion-dollar numbers, one can’t help but wonder: how much is an Alzheimer’s drug worth? This article tries to assess the market value of an Alzheimer’s drug. It first estimates the implied values of Alzheimer’s drugs by looking into stock market reactions to major events associated with Biogen’s Aducanumab and Eli Lilly’s Donanemab. As a sanity check to the values derived from the stock market, a discounted cash flow (DCF) analysis is conducted to evaluate whether the stock market valuations are rational.

USF files patent suit over sale of Alzheimer’s research mice

On Tuesday, March 21st, a pre-trial hearing will take place in a case involving patent infringement claims targeting the sale of mice having mutated genes which make them useful for research into Alzheimer’s disease… The original complaint filed in University of South Florida Board of Trustees v. The Jackson Laboratory, which is in the U.S. District Court for the Middle District of Florida (M.D. Fla.), asserts a single patent: U.S. Patent No. 5898094, entitled Transgenic Mice Expressing APPK670N, M671L and a Mutant Presenilin Transgenes. Issued in April 1999, it protects a transgenic mouse with enhanced Alzheimer’s disease-related amyloid accumulation in its brain produced by selecting the offspring of two mice, one expressing the mutant presenilin encoded in its genes and the other expressing the APPK670N, M671L genetic sequence; this results in a mouse that develops accelerated deposition of amyloid beta in a period of weeks rather than nine months.

Senate passes 21st Century Cures Act, President Obama expected to quickly sign bill into law

Earlier today, by a vote of 94 to 5, the United States Senate overwhelmingly passed the 21st Century Cures Act. Having passed in the House, the Cures Act now goes off to the White House for the President’s signature, where it will receive a warm reception. “I’ll sign it as soon as it reaches my desk, because like a lot of you I’ve lost people I’ve loved deeply to cancer,” President Obama said in his weekly address on December 3, 2016, as he called upon Congress to act swiftly to pass the legislation and send it to the White House.

Putting the pieces together on how to cure Alzheimer’s

The most common form of dementia is Alzheimer’s disease, a progressive disorder of the human brain which over time reduces a person’s cognitive abilities to the point that they cannot carry out the most basic tasks. This terrible disease was thrust back into the national conscious as the result of the death of Nancy Reagan. With this in mind we thought we might take a moment to review what scientists know about Alzheimer’s disease and what treatments and cures are currently being pursued.

Merck, Pfizer and Eli Lilly patenting to stay ahead of patent cliff

The early months of 2015 have been interesting ones for the pharmaceutical industry, an incredibly valuable industry sector that comes under our focus from time to time here at IPWatchdog. The first quarter of this calendar year has seen a number of mergers and acquisitions which are showing us that the patent market for pharmaceuticals is quite active right now.…

The University of California patents treatments for cancer and Alzheimer’s disease

The University of California maintains a portfolio of 11,556 active patent grants. Patented technologies which are currently available for licensing through UC include laser scanners for eye tracking, cardiovascular disorder treatments and environmentally friendly water treatment techniques. In 2013, the Regents of the University of California were issued 399 patents by the U.S. Patent and Trademark Office, tied for 89th-most. A great percentage of UC’s 2014 inventions were related to providing methods involving nucleic acids, host cells and pharmaceutical compositions.

Merck Patents Drugs for Metabolic Disorders & Alzheimer’s

Our survey of the patents recently issued by the USPTO to Merck showed us a great deal of innovation in the field of metabolic disorders and conditions, especially obesity-related diabetes. But one particular patent issued to Merck now protects a pharmaceutical compound inhibiting the activity of gamma secretase and other enzymes involved in the production of amyloid beta. It’s believed that reductions in amyloid protein can treat or even prevent Alzheimer’s disease, making it a very important area of medical research.

Pfizer Focuses Recent Patent Activity on Antibacterial Agents

Patent applications recently published by the U.S. Patent and Trademark Office show that Pfizer’s recent development goals have focused on a broad spectrum of diseases and disorders… Treatments for a number of bacterial infections which can develop in hospital settings was another field of innovation reflected both in Pfizer’s patent applications as well as the patents recently assigned to the company. A couple of recently issued patents protect treatments against gram-negative bacteria by inhibiting a catalyst enzyme necessary for bacterial reproduction.

Patent Granted on Long-Acting Drug for Multiple Sclerosis

The conjugates covered by this patent could enable less frequent and better tolerated dosing of one of the most widely used treatments worldwide for relapsing-remitting multiple sclerosis, interferon-beta-1b. The invention described in the European Patent relates to methods for the preparation of conjugates of poly(ethylene glycol), and derivatives thereof, with interferon-beta-1b. Compared to the corresponding unconjugated bioactive components, the conjugates of the invention have increased stability (i.e., longer shelf life and longer half-lives in vivo). In addition, compared to conjugates of the same bioactive component prepared with polymer chains that are attached randomly to solvent-accessible sites along the polypeptide chains, the conjugates of the invention have increased receptor-binding activity and increased potency.