Posts Tagged: "cancer"

In a research project funded by the Austrian Science Fund (FWF), evidence emerged that a higher expression of the GIRK1 protein in malignant tissue samples was linked to higher relapse and mortality rates in breast cancer patients who have gone through surgery. The novel use of the GIRK1 protein as a biomarker could have a great impact on breast cancer diagnostics and treatments and further research could yield more discovery on the interdependence of GIRK1 with other important biological pathways critical to cancer management… Unfortunately, discovery of GIRK1 as a biomarker for breast cancer diagnostics would run into 35 U.S.C. § 101, the basic threshold statute for determining patentability of subject matter, under the Supreme Court’s March 2012 ruling in Mayo Collaborative Services v. Prometheus Laboratories, Inc. In that case, the Court held that processes involving correlations between blood test results and patient health is not patent-eligible subject matter because the process incorporates laws of nature. This would seemingly render any processes involving the application of GIRK1 as a biomarker for breast cancer prognoses unpatentable as well as the expression of GIRK1 occurs naturally.

Novartis has agreed to acquire French radiopharmaceutical firm Advanced Accelerator Applications (AAA) in a deal which values AAA at $3.9 billion USD. The deal, funded through short- and long-term debt, adds the radioligand therapy (RDL) known as Lutathera to the Novartis pipeline. This drug, approved for use in the European Union and currently undergoing trials for approval by the U.S. Food and Drug Administration (FDA), is used in the treatment of patients suffering from neuroendocrine tumors.

Earlier today, by a vote of 94 to 5, the United States Senate overwhelmingly passed the 21st Century Cures Act. Having passed in the House, the Cures Act now goes off to the White House for the President’s signature, where it will receive a warm reception. “I’ll sign it as soon as it reaches my desk, because like a lot of you I’ve lost people I’ve loved deeply to cancer,” President Obama said in his weekly address on December 3, 2016, as he called upon Congress to act swiftly to pass the legislation and send it to the White House.

A complaint regarding Elekta’s radiotherapy and cancer treatment technologies was filed by Palo Alto, CA-based Varian Medical Systems (NYSE:VAR) in September 2015. The complaint alleged that Elekta violated 19 U.S.C. § 337 which governs penalties for unfair practices in import trade. Varian alleged that Elekta’s medical systems infringe upon a series of six U.S. patents held by Varian.

Of particular interest in this deal is a drug in Celator’s pipeline is Vyxeos (cytarabine:daunorubicin), an injectable liposomal treatment for blood cancers, especially acute myeloid leukemia (AML). The treatment, which has received a Breakthrough Therapy designation from the U.S. Food and Drug Administration (FDA) for fast-tracked approval, recently achieved positive results in a Phase 3 trial. Patients with high-risk, or secondary, AML who received Vyxeos injections saw a significant increase in overall survival rates, 41.5 percent for Vyxeos-treated patients versus 27.6 percent for other patients in a year’s time.

Scientists led by Sriram Subramaniam, PhD, of the National Cancer Institute (NCI) Center for Cancer Research, are using cryo-electron microscopy (cryoEM) to analyze and image molecules, so they can draw conclusions about the way the structure works. At cryogenic temperatures in a range of -180°C to -269°C, they have been able to observe the specimens in their native environment. Simply put, the native state of the samples is preserved in a very thin, liquid, frozen-hydrated film which is rapidly plunged into a liquid ethane bath. Basically, the film is flash frozen with liquid nitrogen. Then, a two dimensional image is captured using electrons. Subsequently, the researchers create thousands of these 2-D images of the molecules in numerous orientations and average them together. What results is a three-dimensional image of the biological object. This technology was named “Method of the Year” for 2015 by Nature Methods.

Earlier this week the National Cancer Institute (NCI), which is part of the National Institutes of Health, announced a Blue Ribbon Panel of scientific experts, cancer leaders, and patient advocates that will work to inform the scientific direction and goals for Vice President Joe Biden’s National Cancer Moonshot Initiative. “Thanks to advances in science, we are now in a historically unique position to make profound improvements in the way we treat, detect, and prevent cancer,” said NIH Director Francis S. Collins, M.D., Ph.D. He is correct, and here is why.

Abbott Laboratories (NYSE:ABT) of Chicago, IL, is poised to surge ahead in the global point-of-care medical diagnostics industry by acquiring Alere Inc. (NYSE:ALR) of Waltham, MA, in a $5.8 billion deal which values Alere at $56 per share. According a recent statement made by Abbott CEO Miles White to investors, the move will push the company’s annual diagnostic sales up to $7 billion. The acquisition is simply the latest major move in the medical device industry, a sector which saw more than 1,000 deals pending or completed last year for a net worth of $58.9 billion, according to statistics published by Bloomberg Business.

February 4 is World Cancer Day… There has been steady progress made in the history of treating cancers of many types since the administration of former U.S President Richard Nixon, according to Dr. Boris Pasche, the Director of the Wake Forest Baptist Medical Center’s Comprehensive Cancer Center. “In my opinion, government should embark on bold new initiatives in cancer treatment,” Pasche said. He did note that, while what President Obama says as a statesman doesn’t change the humbling reality that many cancers have so far stumped medical scientists. Nevertheless, increased investments into cancer research have dramatically impacted survival rates. Over the past decade, most cancers show a better outcome than they did ten years ago. “Bolder initiatives with disruptive approaches to cancer are in order if we want to make leaps forward more quickly,” Pasche said.

Our latest survey of patents issued recently to Canon include a couple of imaging technologies related to medical diagnostics, such as is the case with the imaging innovation outlined within U.S. Patent No. 9230319, entitled Method of Reconstructing a Biological Tissue Image, and Method and Apparatus for Acquiring a Biological Tissue Image. It protects a method of reconstructing an image of a sample through the use of multiple measured spectra obtained by measuring respective regions of the sample; the method involves acquiring an image through utilization of an intensity distribution in the regions of at least one peak in each of the measured spectra as well as a classifier. This technique is useful in the examination of biological tissues to determine the presence of cancer.

To hear Ars Technica say it is ”a terrible idea” to devote increased funding in order to eradicate cancer is astonishing on many levels. As part of the reason why he believes increased funding for cancer research is a terrible idea he explains that great strides have been made with respect to treatments and cures, which is true. Of course, it is also true that people are dying and they are dying horrible deaths. With the victories and advances that have been made over the last generation it is no longer fanciful to dream of a day when cancer can become eradicated. So why is it a terrible idea to devote more resources on a so-called cancer moonshot to attempt to once and for all put an end to this scourge? For anyone to call President Obama’s cancer moonshot a terrible idea is nothing short of cruel, and is frankly incredibly stupid.

Drugs for the treatment of late-stage cancers are less expensive to develop, in part because late-stage drugs extend patients’ lives for a shorter period of time such that clinical trials are concluded more quickly. This means that such drugs require less time to research, develop, test and bring to market than drugs that treat earlier stage cancers, providing the innovator with a longer effective patent life. In essence, less research and development investment is directed toward drugs that treat patient groups requiring lengthy clinical trials, those with longer commercialization lags… It’s worthwhile to ask whether a ‘one-size-fits-all’ patent policy is optimal. How we can think creatively about patent protection in an effort to incentivize the innovation we want and push the frontiers of modern medicine.

Bristol-Myers Squibb was able to move on in clinical trials of its cancer drug Opvido more quickly than anticipated after kidney cancer patients who were administered the medication showed superior overall survival compared to those patients who were not on an Opvido regimen. Opvido, which has already been approved by the U.S. Food and Drug Administration for the treatment of advanced melanomas and lung cancers, is an inhibitor of the protein known as programmed cell death protein 1, or PD-1. PD-1 inhibits the response of T cell lymphocytes, making it more difficult for an immune system to target a tumor.